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All these clinical safety data are consistent with the published phase II 24-month follow-up study data and support that Jintrolong® can increase convenience and compliance rein GHD children without increasing safety concerns.
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Figure 6 shows representative images of CP tissue stained with an antibody against Ki-67. There are only a few positive cells (+) or no positive cells (−) hinein the brain CP tissue of cynomolgus monkeys hinein most animals, except for one animal rein the 3 mg/kg/week group, which had multiple positive cells rein the CP(++).
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As shown rein Figures 8A, B, the severity of vacuolation hinein the CP epithelium increases with dose by both average vacuole size and average vacuole ratio (cells with vacuole/total CP epithelial cells). As shown rein Figure 8C, no vacuolation welches considered to be induced by Jintrolong® in the low dose of 0.3 mg/kg/week Jintrolong® group, as vacuolation was within the background vacuolation Auswahl hinein the excipient control group.
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Since the vacuolation rein CP welches Jintrolong® dose- and time-dependent, the vacuolation rein CP was likely induced by Jintrolong®, which welches further confirmed by the PEG presence rein the vacuolation by EMT and IHC described afterward.
If this medicine is used for weight loss/muscle wasting, it may take up to 2 weeks to notice the effects of the drug. Do not use more of this medication than prescribed or use it more often since the risk of side effects will Beryllium increased.
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Km is the Michaelis constant, and Vmax is the maximum Tarif of elimination of the nonlinear pathway. Vc is the volume of Verteilung of the central compartment. fluor stands for bioavailability.
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The CP cells of each group under TEM were cubic, with abundant microvilli on the surface, and the tight junctions between the cells and the basement membrane on the bottom were intact.